[April 2013 organizational change]
Reborn as IMS to explore new research possibilities > Center for Integrative Medical Sciences
Laboratories

Laboratory for International Alliance

Ming Ta Michael LEE

Laboratory HeadMing Ta Michael LEE (Ph.D.)

Developing personalized medicine for all through research cooperation and international recruitment of young researchers

As part of the international HapMap Project, the Center for Genomic Medicine laid the groundwork for SNP research by constructing Haplotype maps for Caucasians, Asians and Africans, an this work suggested that the Haplotype patterns of Japanese are similar to those of other Asians. Since one of the center’s overall goals is to provide better medical care and improve health in Asia, this similarity will be useful for SNP research in Asian populations. By conducting comparative studies, it will be possible to illuminate ethnic similarities or differences in pathophysiological mechanisms of diseases and drug responses among patients.

The Laboratory for International Alliance supports SNP-based research using the center’s technologies and knowledge in areas where SNP-based research for disease genes is not well developed. We actively recruit young scientists from overseas to work at RIKEN and carry out research in SNP-based approach, statistical analysis and biological analysis. Our long-term goal is to establish an international SNP research network that will make the Center for Genomic Medicine a world leader in personalized medicine. We have already initiated four projects as part of these efforts: a study of the genes related to skin rashes induced by Nevirapine, one of the HIV drugs (joint project with TCEL and Mahidol University, Thailand), a study of genes related to Leber’s disease (Mahidol University, Thailand), a study of susceptibility genes for nasopharyngeal cancer (Malaya University, Malaysia), and a study of genes associated with susceptibilities for schizophrenia and bipolar disorder (Medical University of Sofia, Bulgaria).

Research Subjects

  • (1)   Nevirapine-induced skin rash in Thai HIV patients
  • (2)   Nuclear modifier genes for expression of Thai Leber hereditary optic neuropathy
  • (3)   Identification of genes associated with schizophrenia and bipolar disorder in Bulgarians
  • (4)   Identification of genes associated with nasopharyngeal carcinoma in Malaysian Chinese
  • (5)   Identification of genes associated with tuberculosis in Thai patients

List of Selected Publications

  • (1)   Yosifova A, Mushiroda T, Stoianov D, Vazharova R, Dimova I, Karachanak S, Zaharieva I, Milanova V, Madjirova N, Gerdjikov I, Tolev T, Velkova S, Kirov G, Owen MJ, O'Donovan MC, Toncheva D, Nakamura Y
    Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population
    J Affect Disord 117: 87-97 (2009)
  • (2)   Betcheva ET, Mushiroda T, Takahashi A, Kubo M, Karachanak SK, Zaharieva IT, Vazharova RV, Dimova II, Milanova VK, Tolev T, Kirov G, Owen MJ, O'Donovan MC, Kamatani N, Nakamura Y, Toncheva DI
    Case-control association study of 59 candidate genes reveals the DRD2 SNP rs6277 (C957T) as the only susceptibility factor for schizophrenia in the Bulgarian population
    J Hum Genet 54: 98-107 (2009)
  • (3)   Chantarangsu S, Mushiroda T, Mahasirimongkol S, Kiertiburanakul S, Sungkanuparph S, Manosuthi W, Tantisiriwat W, Charoenyingwattana A, Sura T, Chantratita W, Nakamura Y
    HLA-B*3505 allele is a strong predictor for nevirapine-induced skin adverse drug reactions in HIV-infected Thai patients
    Pharmacogenet Genomics 19: 139-46 (2009)
  • (4)   Mushiroda T, Wattanapokayakit S, Takahashi A, Nukiwa T, Kudoh S, Ogura T, Taniguchi H, Kubo M, Kamatani N, Nakamura Y; Pirfenidone Clinical Study Group
    A genome-wide association study identifies an association of a common variant in TERT with susceptibility to idiopathic pulmonary fibrosis
    J Med Genet 45: 654-6 (2008)